The best way to accomplish your goal is to make Flatpaks of those Windows games that either bundle Wine or use a shared Wine runtime. And while that’s not one of Endless’s own goals, there are people working on it and we will benefit from that work.
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How to install the Winepak repository in Endless OS Tutorial: https://community.endlessos.com/t/how-to-install-the-winepak-repository-in-endless-os/6856