OUTDATED - USE TOOLBOX (PODMAN) TO RUN FEDORA INSIDE EOS AND INSTALL THE LATEST WINE IN THERE.
As this question always pops up from time to time, i published my current solution to the wild:
Essentially, it’s a flatpak of Microsoft’s WinFile (which has been open sourced some time ago) running under Wine from Winepak. Follow the build instructions to set up your Wine based environment and run any Wine supported Windows applications.